ABSTRACT
Objective:To explore the correlation between combined detection of serum high sensitive troponin T (hscTnT),homocysteine (Hcy) and high sensitive C reactive protein (hsCRP) and diagnostic positive rates of coro-nary heart disease (CHD).Methods:A total of 95 CHD patients were selected,including 35 cases with stable angina pectoris (SAP),30 cases with unstable angina pectoris (UAP) and 30 cases with acute myocardial infarction (AMI).According to results of coronary angiography,patients were divided into mild stenosis group (n＝31),moderate ste-nosis group (n＝34) and severe stenosis group (n＝30).Another 95 healthy subjects were enrolled as healthy control group.Levels of hscTnT,Hcy and hsCRP were measured and compared among all groups,positive rates of single and combined detection were measured,and correlation among coronary disease severity,serum levels of hscTnT,Hcy,hsCRP and their combined detection were analyzed.Results:Serum levels of hscTnT,Hcy and hsCRP in CHD group were significantly higher than those of healthy control group,P＝0.001 all.Hcy positive rates of UAP and AMI group were significantly higher than that of SAP group (63.33%,70.00% vs.14.29%,P＝0.001 all).There was no significant difference in positive rate of combined detection (91.43%,93.33%,96.67%) among SAP group,UAP group and AMI group ( P＞0.05 all),but all of them were significantly higher than those of single de-tection,P＜0.05 or ＜ 0.01.Positive rates of hscTnT and hsCRP diagnosing SAP were significantly higher than that of Hcy (68.57%,71.43% vs.14.29%,P＝0.001 all).Compared with mild stenosis group,there were signifi-cant rise in serum levels of hscTnT,Hcy and hsCRP in moderate and severe stenosis group,and those of severe ste-nosis group were significantly higher than those of moderate stenosis group (P＝0.001 all).Biviarate Spearman a-nalysis indicated that serum levels of hscTnT,Hcy and hsCRP,their combined detection results were significant pos-itively correlated with coronary disease severity in CHD patients (r＝0.512～0.813,P＜0.01 all).Conclusion:Pos-itive rate of combined detection of serum hscTnT,Hcy and hsCRP is significantly higher than those of single detec-tion in CHD patients.Combined diagnostic result is significant positively correlated with coronary disease severity.